Cellular reprogramming to study intellectual disability and neurodevelopmental disorders
نویسندگان
چکیده
منابع مشابه
Cellular reprogramming to study intellectual disability and neurodevelopmental disorders
Introduction Many neurodevelopmental disorders with intellectual disability and autism spectrum disorder syndromes have overlapping genetic and molecular connections. Effective treatments for such genetic neurodevelopmental disorders have not been established yet. Possible reasons include the lack of suitable disease models of human neurons and a limited understanding of the etiological and neu...
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It is becoming increasingly important to understand how epigenetic mechanisms control gene expression during neurodevelopment. Two epigenetic mechanisms that have received considerable attention are DNA methylation and histone acetylation. Human exome sequencing and genome-wide association studies have linked several neurobiological disorders to genes whose products actively regulate DNA methyl...
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Brain function and behavior undergo significant plasticity and refinement, particularly during specific critical and sensitive periods. In autistic and intellectual disability (ID) neurodevelopmental disorders (NDDs) and their corresponding genetic mouse models, impairments in many neuronal and behavioral phenotypes are temporally regulated and in some cases, transient. However, the links betwe...
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There is accumulating evidence for shared genetic as well as environmental risk between intellectual disability and other conditions with a neurodevelopmental basis such as autism, attention-deficit hyperactivity disorder, epilepsy and schizophrenia. These can be conceived as lying along a continuum of genetically and environmentally induced neurodevelopmental causality.
متن کاملMood disorders in intellectual disability.
PURPOSE OF REVIEW This article examines reviews and research on the diagnosis and treatment of mood disorders in people with intellectual disability published from September 2004 to December 2005. RECENT FINDINGS Patients with intellectual disability have limitations in verbal ability, and with increasing levels of disability may have an atypical clinical presentation. Thus, methods to diagno...
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ژورنال
عنوان ژورنال: OA Biochemistry
سال: 2013
ISSN: 2052-9651
DOI: 10.13172/2052-9651-1-1-443